Social cognition and executive function in borderline personality disorder: evidence of altered cognitive processes
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Resumen
Objetivo. Evaluar la contribución de SC y EF en los patrones cognitivos en el TLP, así como investigar las posibles relaciones entre SC, EF y las características clínicas del TLP.
Método. El estudio evaluó 20 mujeres con TLP en hospitalización ambulatoria y 20 mujeres sanas en cognición social (“Leer la mente a través de los ojos” y la tarea de apuestas IOWA) y función ejecutiva (con la Prueba de clasificación de tarjetas de Wisconsin, tareas de fluidez verbal; y números y letras del WAIS-III, formulario de prueba de Trail Making A y B).
Resultados. Se evidencian diferencias estadísticamente significativas en cognición social, la teoría de la mente (p < .001**) y la tarea de apuestas IOWA, puntúan IOWA 4 (p < .004 *) e IOWA 5 (p < .003*) y en funciones ejecutivas; por ejemplo, en la prueba de clasificación de tarjetas de Wisconsin, se encontraron WCST1 (p < .003*), WCST2 (p < .004*), WCST3 (p < .018*) o WCST4 (p < .003*). Además, la prueba de amplitud de dígitos o la fluidez verbal tuvieron diferencias significativas en comparación con los controles.
Discusión y conclusión. Los subdominios evaluados serían buenos endofenotipos, así como también procesos cognitivos específicos para investigación y rehabilitación.
Referencias
American Psychiatric Association, 2013. (2013). Diagnostic and Stadistical Manual of Mental Disorders. Fifth Edition. Washington.
Andreou, C., Kelm, L., Bierbrodt, J., Braun, V., Lipp, M., Yassari, A. H., & Moritz, S. (2015). Factors contributing to social cognition impairment in borderline personality disorder and schizophrenia. Psychiatry Research, 229(3), 872–879. http://doi.org/10.1016/j.psychres.2015.07.057
Arntz, A., Bernstein, D., Oorschot, M., & Schobre, P. (2009). Theory of mind in borderline and cluster-C personality disorder. The Journal of Nervous and Mental Disease, 197(11), 801–807. http://doi.org/10.1097/NMD.0b013e3181be78fb
Arntz, A., & Haaf, J. Ten. (2012). Social cognition in borderline personality disorder: Evidence for dichotomous thinking but no evidence for less complex attributions. Behaviour Research and Therapy, 50(11), 707–718. http://doi.org/10.1016/j.brat.2012.07.002
Arza, R., Díaz Marsá, M., López Micó, C., Fernández de Pablo1, N., López Ibor, J. J., & Carrasco, J. L. (2009). Rehabilitación neuropsicológica en pacientes con trastorno límite de personalidad: una serie de casos. Actas Españolas de Psiquiatria, 37(4), 236–239.
Baron-Cohen, S., Leslie, a M., & Frith, U. (1985). Does the autistic child have a “theory of mind”? Cognition, 21(1), 37–46. http://doi.org/10.1016/0010-0277(85)90022-8
Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The “Reading the Mind in the Eyes” Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 42(2), 241–251. http://doi.org/10.1111/1469-7610.00715
Bechara, A., Damasio, A., Damasio, H., & Anderson, S. (1994). “Insensitivity to future consequences following damage to human prefrontal cortex”. Cognition, 50: 7-12.
Bechara, A. (2004). The role of emotion in decision-making: Evidence from neurological patients with orbitofrontal damage. Brain and Cognition, 55(1), 30–40. http://doi.org/10.1016/j.bandc.2003.04.001
Bechara, A. (2005). Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nature Neuroscience, 8(11), 1458–1463. http://doi.org/10.1038/nn1584
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. (2005). The Iowa Gambling Task and the somatic marker hypothesis: some questions and answers. Trends in Cognitive Science, 9: 159-62.
Brevers, D., Bechara, A., Cleeremans, A., & Noël, X. (2013). Iowa Gambling Task (IGT): twenty years after - gambling disorder and IGT. Frontiers in Psychology, 4, 665. http://doi.org/10.3389/fpsyg.2013.00665
Cullen, K., Vizueta, N., Thomas, K., Han, G., Lim, K., Camchong, J., Mueller, B., Bell, C., Heller, M., & Schulz, C. (2011). Amygdala Functional Connectivity in Young Women with Borderline Personality Disorder. Brain Connectivity, 1(1): 61-71. DOI: 10.1089/brain.2010.0001.
Damasio, A. (1994). Descartes Error. Chile: Editorail Adndés Bello.
De la Cruz, M. (2001. Test de Clasificación de Tarjetas de Wisconsin. Manual (2da. Edición). Madrid: Ediciones TEA.
Dyck, M., Habel, U., Slodczyk, J., et al. (2009). Negative bias in fast emotion discrimination in borderline personality disorder. Psychological Medicine, 39(5): 855–64.
Domes, G., Schulze, L., & Herpertz, S. C. (2009). Emotion recognition in borderline personality disorder-a review of the literature. Journal of Personality Disorders, 23(1), 6–19. http://doi.org/10.1521/pedi.2009.23.1.6
Fernández-Abascal, E. G., Cabello, R., Fernández-Berrocal, P., & Baron-Cohen, S. (2013). Test-retest reliability of the “Reading the Mind in the Eyes” test: a one-year follow-up study. Molecular Autism, 4(1), 33. http://doi.org/10.1186/2040-2392-4-33
Fertuck, E. a, Jekal, a, Song, I., Wyman, B., Morris, M. C., Wilson, S. T., Stanley, B. (2009). Enhanced’Reading the Mind in the Eyes' in borderline personality disorder compared to healthy controls. Psychological Medicine, 39(12), 1979. http://doi.org/10.1017/S003329170900600X.Enhanced
Fertuck, E. a., Lenzenweger, M. F., Clarkin, J. F., Hoermann, S., & Stanley, B. (2006). Executive neurocognition, memory systems, and borderline personality disorder. Clinical Psychology Review, 26(3), 346–375. http://doi.org/10.1016/j.cpr.2005.05.008
Forti, L., & Forti, A. (2012). Trastorno límite de la personalidad y conductas autolíticas. Revista Española de Medicina Legal, 38(4). doi: 10.1016/j.reml.2012.08.001.
Fonagy, P., & Bateman, A. (2008). The development of borderline personality disorder a mentalizing model. Journal of Personality Disorders, 22(1): 4–21.
Franzen, N., Hagenhoff, M., Baer, N., Schmidt, A., Mier, D., Sammer, G., Gallhofer, B., Kirsh, P., & Lis, S. (2011). Superior Theory of Mind in borderline personality disorder: an analysis of interaction behavior in a virtual trust game. Psychiatry Research, 187: 224–233.
Frick, C., Lang, S., Kotchoubey, B., Sieswerda, S., Dinu-Biringer, R., Berger, M., Barnow, S. (2012). Hypersensitivity in borderline personality disorder during mindreading. PLoS ONE, 7(8), 4–11. http://doi.org/10.1371/journal.pone.0041650
Gavilán-Ibáñez, J. M., & García-Albea, J. E. (2013). Theory of mind and language comprehension in schizophrenia. Psicothema, 25(4), 440–445. http://doi.org/10.7334/psicothema2012.357
Gottesman, I., & Gould, T. (2003). The Endophenotype concept in psychiatry: Etymology and Strategic Intentions. Am J Psychiatry, 160:636-645
Gvirts, H., Harari, H., Braw, Y., Shefet, D., Shamay-Tsoory, S., & Levkovitz, Y. (2012). Executive functioning among patients with borderline personality disorder and their relatives. Journal of Affective Disorders, 143: 261–264.
Grosjean, B., & Tsai, G. (2007). NMDA neurotransmission as a critical mediator of borderline personality disorder. J Psychiatry Neurosci., 32(2): 103-115
Hagenhoff, M., Franzen, N., Koppe, G., Baer, N., Scheibel, N., Sammer, G., Gallhofer, B., & Lis, S. (2013). Executive functions in borderline personality disorder. Psychiatry Research, 210: 224-231.
Homberg, J. (2012). Serotonin and decision making processes. Neuroscience and Biobehavioral Reviews, 36: 218–236.
Hughes, A. E., Crowell, S. E., & Coan, J. a. (2012). A developmental neuroscience of borderline pathology: emotion dysregulation and social baseline theory.J Abnorm Child Psychol., 40(1): 21–33. DOI: 10.1007/s10802-011-9555-x.
Igarashi, H., Hasui, C., Uji, M., Shono, M., Nagata, T., & Kitamura, T. (2010). Effects of child abuse history on borderline personality traits, negative life events, and depression: A study among a university student population in Japan. Psychiatry Research, 180(2-3), 120–125. http://doi.org/10.1016/j.psychres.2010.04.029
Jaichenco, V., Wilson, M., Ruiz, A. (2007). Evaluación del lenguaje. En Burin D, Drake M, Harris P, (compiladoras). Evaluación neuropsicológica en adultos. Paidós: Argentina.
Jacob A., G. a., Zvonik, K., Kamphausen, S., Sebastian, A., Maier, S., Philipsen, A., Tüscher, O. (2013). Emotional modulation of motor response inhibition in women with borderline personality disorder: An fMRI study. Journal of Psychiatry and Neuroscience, 38(3), 164–172. http://doi.org/10.1503/jpn.120029
Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014). The role of DNA methylation in stress-related psychiatric disorders. Neuropharmacology, 80, 115–132. http://doi.org/10.1016/j.neuropharm.2014.01.013
LeGris, J., Links, P. S., Van Reekum, R., Tannock, R., & Toplak, M. (2012). Executive function and suicidal risk in women with Borderline Personality Disorder. Psychiatry Research, 196(1), 101–108. http://doi.org/10.1016/j.psychres.2011.10.008
Leichsenring, F., Leibing, E., Kruse, J., New, A. S., & Leweke, F. (2011). Borderline personality disorder. The Lancet, 377(9759), 74–84. http://doi.org/10.1016/S0140-6736(10)61422-5
Lynch, T., Rosenthal, M., Kosson, D., Cheavens, J., Lejuez, C., Blair, R. (2006) .Heightened sensitivity to facial expressions of emotion in borderline personality disorder. Emotion, 6(4): 647–55.
Maurex, L., Zaboli, G., Ohman, A., Asberg, M., & Leopardi, R. (2010). The serotonin transporter gene polymorphism (5-HTTLPR) and affective symptoms among women diagnosed with borderline personality disorder. European Psychiatry, 25: 19–25.
Maurex, L, Zaboli, G., Wiens, S., Asberg, M., Leopardi, R., & Ohman, A. (2009). Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder. Scandinavian Journal of Psychology, 50: 5–10.
McGowan, P. O., & Szyf, M. (2010). The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiology of Disease, 39(1), 66–72. http://doi.org/10.1016/j.nbd.2009.12.026
McCloskeya, M., New, A., Siever, L., Goodman, M., Koenigsberg, H., Flory, J., & Coccaro, E. (2009). Evaluation of behavioral impulsivity and aggression task as endophenotypes of borderline personality disorder. J Psychiatr Res, 43(12): 1036–1048. DOI:10.1016/j.jpsychires.2009.01.002.
Mier, D., Lis, S., Esslinger, C., Sauer, C., Hagenhoff, M., Ulferts, J.,
Gallhofer, B., & Kirsch, P. (2013). Neuronal correlates of social cognition in borderline personality disorder. Social Cognitive and Affective Neuroscience, 8(5), 531–537. http://doi.org/10.1093/scan/nss028
Miller, E. The prefrontal cortex and cognitive control. Nat. Rev. Neurosci., 1: 59–65.
Montero, I., & León, O. G. (2007). A guide for naming research studies in Psychology. International Journal of Clinical and Health Psychology, 7(3), 847–862.
Mueller, S. T., & Piper, B. J. (2014). The Psychology Experiment Building Language (PEBL) and PEBL Test Battery. Journal of Neuroscience Methods, 222, 250–9. http://doi.org/10.1016/j.jneumeth.2013.10.024
O’Neill, A., D’Souza, A., Samson, A. C., Carballedo, A., Kerskens, C., & Frodl, T. (2014). Dysregulation between emotion and theory of mind networks in borderline personality disorder. Psychiatry Research, 231(1), 25–32. http://doi.org/10.1016/j.pscychresns.2014.11.002
Paris J. (2008). Treatment of Borderline Personality Disorder: Guide to Evidence Based Practice New York: Guilford Press.
Pope, H., Jonas, J., Hudson, J., et al. (1985). An empirical study of psychosis in borderline personality disorder. Am J Psychiatry, 142:1285–1290.
Preißler, S., Dziobek, I., Ritter, K., Heekeren, H. R., & Roepke, S. (2010). Social Cognition in Borderline Personality Disorder: Evidence for Disturbed Recognition of the Emotions, Thoughts, and Intentions of others, 4(December), 8. http://doi.org/10.3389/fnbeh.2010.00182
Hernández, R., Fernández, C., Baptista, P. (2010). Metodología de la Investigación. 5ª.ed., México DF, Editorial Mc Graw Hill Interamericana.
Robin, M., Pham-Scottez, A., Curt, F., Dugre-Le Bigre, C., Speranza, M., Sapinho, D., Kedia, G. (2012). Decreased sensitivity to facial emotions in adolescents with Borderline Personality Disorder. Psychiatry Research, 200(2-3), 417–421. http://doi.org/10.1016/j.psychres.2012.03.032
Roepke, S., Vater, A., Preißler, S., Heekeren, H. R., & Dziobek, I. (2012). Social cognition in borderline personality disorder. Frontiers in Neuroscience, 6(JAN), 1–12. http://doi.org/10.3389/fnins.2012.00195
Sabbagh, M. (2004). Understanding orbitofrontal contributions to theory-of-mind reasoning: implications for autism. Brain and Cognition, 55:209-219.
Svaldi, J., Philipsen, A., & Matthies, S. (2012). Risky decision-making in borderline personality disorder. Psychiatry Research, 197(1-2), 112–118. http://doi.org/10.1016/j.psychres.2012.01.014
Silvio, V. (2005). Funciones fronto-temporales en pacientes diagnosticados con trastorno límite de la personalidad. Archivos Venezolanos de Psiquiatría y Neurología, 15(104): 30-35.
Stevens, A., Burkhardt, M., Hautzinger, M., Schwarz, J., & Unckel, C. (2004). Borderline personality disorder: Impaired visual perception and working memory. Psychiatry Research, 125: 257–267.
Tajima, K., Montes, a., García-Andrade, R. F., Casado, a., Carrasco, J. L., & Diaz-Marsá, M. (2009). Estudios de neuroimagen en el trastorno límite de la personalidad. Actas Espanolas de Psiquiatria, 37(3), 123–127.
Tajima, M., y de Anta, L. (2009). Trastornos de Personalidad. En Munárriz, M., García-Portilla, P., y Roca, M. Manual del Residente en Psiquiatría I. Asociación Española de Psiquiatría (AEN), la Sociedad Española de Psiquiatría (SEP) y la Sociedad Española de Psiquiatría Biológica (SEPB), 2009. Madrid: España.
Tebartz, L., Hesslinger, B., Thiel, T., Geiger, E., Haegele, K., Lemieux, L., Lieb, K., Bohus, M., Hennig, J. & Ebert, D. (2003). Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biological Psychiatry, 54: 163–171.
Toplak, M. E., Sorge, G. B., Benoit, A., West, R. F., & Stanovich, K. E. (2010). Decision-making and cognitive abilities: A review of associations between Iowa Gambling Task performance, executive functions, and intelligence. Clinical Psychology Review, 30(5), 562–581. http://doi.org/10.1016/j.cpr.2010.04.002
Unoka, Z., Fogd, D., Füzy, M., & Csukly, G. (2011). Misreading the facial signs: Specific impairments and error patterns in recognition of facial emotions with negative valence in borderline personality disorder. Psychiatry Research, 189(3), 419–425. http://doi.org/10.1016/j.psychres.2011.02.010
Vaskinn, A., Antonsen, B. T., Fretland, R. a., Dziobek, I., Sundet, K., & Wilberg, T. (2015). Theory of mind in women with borderline personality disorder or schizophrenia: differences in overall ability and error patterns. Frontiers in Psychology, 6(August), 1–7. http://doi.org/10.3389/fpsyg.2015.01239
Villodre, R., Sánchez-Alfonso, A., Brines, L., Núñez, A., Chirivella, J., Ferri, J., Noé, E. (2006).Fluencia verbal: estudio normativo piloto según estrategias de «agrupación» y «saltos» de palabras en población española de 20 a 49 años. Neurología, 21(3):124-130.
Wechsler, D. (1997). WAISS-III Manual, San Antonio. The Psychological Corporation.
Wolf, R., Sambataro, F., Vasic, N., Schmid, M., Thomann, P., Bienentreu, S., Wolf, N. (2011). Aberrant connectivity of resting-state networks in borderline personality disorder. J Psychiatry Neurosci, 36(6):402-11. DOI: 10.1503/jpn.100150.
Yee, L., Korner, A., McSwiggan, S., et al. (2005). Persistent hallucinosis in borderline personality disorder. Compr Psychiatry, 46:147–154.
Zanarini, M. (2000). Childhood experiences associated with the development of borderline personality disorder. Psychiatric Clinics of North America, 23: 89-101.
