Advanced paternal age as a risk factor for autism spectrum disorder in a Mexican population
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Resumen
Objetivo. El presente trabajo tiene el objetivo de analizar si la edad parental avanzada es un factor de riesgo para TEA en una muestra de niños mexicanos.
Método. Un total de 1 068 niños de la Ciudad de México se incluyeron en un estudio de casos-controles, de los cuáles 162 contaban con diagnóstico de TEA. Regresiones logísticas multivariable, ajustadas por confusores, se realizaron para explorar el efecto de la edad parental avanzada en el riesgo para TEA.
Resultados. La edad paterna avanzada en niños mexicanos aumentó el riesgo para TEA; también, una diferencia de edad de 10 años entre los padres presenta un mayor riesgo.
Discusión y conclusión. El efecto de la edad paterna avanzada en los niños mexicanos fue mucho más bajo que aquella reportada para otras poblaciones. La edad paterna avanzada y la diferencia entre la edad parental puede ser un factor de riesgo para TEA en población mexicana. Sin embargo, se requieren análisis en poblaciones con mayor tamaño de muestra.
Referencias
Albores-Gallo, L., Roldán-Ceballos, O., Villarreal-Valdes, G., Betanzos-Cruz, B. X., Santos-Sánchez, C., Martínez-Jaime, M. M., Lemus-Espinosa, I., & Hilton, C. L. (2012). M-CHAT Mexican Version Validity and Reliability and Some Cultural Considerations. ISRN Neurology, 2012, 1-7. doi: 10.5402/2012/408694
Baxter, A. J., Brugha, T. S., Erskine, H. E., Scheurer, R. W., Vos, T., & Scott, J. G. (2015). The epidemiology and global burden of autism spectrum disorders. Psychological Medicine, 45(3), 601-613. doi: 10.1017/s003329171400172x
Becerra, T. A., von Ehrenstein, O. S., Heck, J. E., Olsen, J., Arah, O. A., Jeste, S. S., ... Ritz, B. (2014). Autism Spectrum Disorders and Race, Ethnicity, and Nativity: A Population-Based Study. Pediatrics, 134(1), e63-e71. doi: 10.1542/peds.2013-3928
Bilder, D., Pinborough-Zimmerman, J., Miller, J., & McMahon, W. (2009). Prenatal, Perinatal, and Neonatal Factors Associated With Autism Spectrum Disorders. Pediatrics, 123(5), 1293-1300. doi: 10.1542/peds.2008-0927
Buizer-Voskamp, J. E., Laan, W., Staal, W. G., Hennekam, E. A. M., Aukes, M. F., Termorshuizen, F., ... Ophoff, R. A. (2011). Paternal age and psychiatric disorders: Findings from a Dutch population registry. Schizophrenia Research, 129(2-3), 128-132. doi: 10.1016/j.schres.2011.03.021
Burstyn, I., Sithole, F., & Zwaigenbaum, L. (2010). Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada. Chronic Diseases in Canada, 30(4), 125-134.
Buwe, A., Guttenbach, M., & Schmid, M. (2005). Effect of paternal age on the frequency of cytogenetic abnormalities in human spermatozoa. Cytogenetic and Genome Research, 111(3-4), 213-228. doi: 10.1159/000086892
Christiansz, J. A., Gray, K. M., Taffe, J., & Tonge, B. J. (2016). Autism Spectrum Disorder in the DSM-5: Diagnostic Sensitivity and Specificity in Early Childhood. Journal of Autism and Developmental Disorders, 46(6), 2054-2063. doi: 10.1007/s10803-016-2734-4
Croen, L. A., Najjar, D. V., Fireman, B., & Grether, J. K. (2007). Maternal and Paternal Age and Risk of Autism Spectrum Disorders. Archives of Pediatrics & Adolescent Medicine, 161(4), 334-340. doi: 10.1001/archpedi.161.4.334
Crow, J. F. (2000). The origins, patterns and implications of human spontaneous mutation. Nature Reviews. Genetics, 1(1), 40-47. doi: 10.1038/35049558
de Kluiver, H., Buizer-Voskamp, J. E., Dolan, C. V., & Boomsma, D. I. (2017). Paternal age and psychiatric disorders: A review. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 174(3), 202-213. doi: 10.1002/ajmg.b.32508
Durkin, M. S., Maenner, M. J., Newschaffer, C. J., Lee, L., Cunniff, C. M., Daniels, J. L., Kirby, R. S., Leavitt, L., Miller, L., Zahorodny, W., & Schieve, L. A. (2008). Advanced Parental Age and the Risk of Autism Spectrum Disorder. American Journal of Epidemiology, 168(11), 1268-1276. doi: 10.1093/aje/kwn250
D’Onofrio, B. M., Rickert, M. E., Frans, E., Kuja-Halkola, R., Almqvist, C., Sjölander, A., ... Lichtenstein, P. (2014). Paternal Age at Childbearing and Offspring Psychiatric and Academic Morbidity. JAMA Psychiatry, 71(4), 432-438. doi: 10.1001/jamapsychiatry.2013.4525
Elsabbagh, M., Divan, G., Koh, Y., Kim, Y. S., Kauchali, S., Marcín, C., ... Fombonne, E. (2012). Global Prevalence of Autism and Other Pervasive Developmental Disorders. Autism Research, 5(3), 160-179. doi: 10.1002/aur.239
Flatscher-Bader, T., Foldi, C. J., Chong, S., Whitelaw, E., Moser, R. J., Burne, T. H. J., … McGrath, J. J. (2011). Increased de novo copy number variants in the offspring of older males. Translational Psychiatry, 1(8), e34. doi: 10.1038/tp.2011.30
Fombonne, E., Marcin, C., Manero, A. C., Bruno, R., Diaz, C., Villalobos, M., ... Nealy, B. (2016). Prevalence of Autism Spectrum Disorders in Guanajuato, Mexico: The Leon survey. Journal of Autism and Developmental Disorders, 46(5), 1669-1685. doi: 10.1007/s10803-016-2696-6
Frans, E. M., Sandin, S., Reichenberg, A., Långström, N., Lichtenstein, P., McGrath, J. J., & Hultman, C. M. (2013). Autism Risk Across GenerationsA Population-Based Study of Advancing Grandpaternal and Paternal Age. JAMA Psychiatry, 70(5), 516-521. doi: 10.1001/jamapsychiatry.2013.1180
Gillberg, C., Schaumann, H., & Gillberg, I. C. (1995). Autism in immigrants: children born in Sweden to mothers born in Uganda. Journal of Intellectual Disability Research, 39(2), 141-144. doi: 10.1111/j.1365-2788.1995.tb00482.x
Gillberg, C., Steffenburg, S., Börjesson, B., & Andersson, L. (1987). Infantile Autism in Children of Immigrant Parents: A Population-based Study from Göteborg, Sweden. British Journal of Psychiatry, 150(6), 856-858. doi: 10.1192/bjp.150.6.856
Glasson, E. J., Bower, C., Petterson, B., de Klerk, N., Chaney, G., & Hallmayer, J. F. (2004). Perinatal Factors and the Development of Autism: A Population Study. Archives of General Psychiatry, 61(6), 618-627. doi: 10.1001/archpsyc.61.6.618
Golding, J., Steer, C., & Pembrey, M. (2010). Parental and Grandparental Ages in the Autistic Spectrum Disorders: A Birth Cohort Study. PLoS ONE, 5(4), e9939. doi: 10.1371/journal.pone.0009939
Grether, J. K., Anderson, M. C., Croen, L. A., Smith, D., & Windham, G. C. (2009). Risk of Autism and Increasing Maternal and Paternal Age in a Large North American Population. American Journal of Epidemiology, 170(9), 1118-1126. doi: 10.1093/aje/kwp247
Hultman, C. M., Sandin, S., Levine, S. Z., Lichtenstein, P., & Reichenberg, A. (2011). Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies. Molecular Psychiatry, 16(12), 1203-1212. doi: 10.1038/mp.2010.121
Idring, S., Magnusson, C., Lundberg, M., Ek, M., Rai, D., Svensson, A. C., … Lee, B. K. (2014). Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort. International Journal of Epidemiology, 43(1), 107-115. doi: 10.1093/ije/dyt262
Janecka, M., Mill, J., Basson, M. A., Goriely, A., Spiers, H., Reichenberg, A., ... Fernandes, C. (2017). Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms. Translational Psychiatry, 7(1), e1019-e1019. doi: 10.1038/tp.2016.294
Jenkins, T. G., Aston, K. I., Pflueger, C., Cairns, B. R., & Carrell, D. T. (2014). Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility. PLoS Genetics, 10(7), e1004458. doi: 10.1371/journal.pgen.1004458
Kent, R. G., Carrington, S. J., Le Couteur, A., Gould, J., Wing, L., Maljaars, J., … Leekam, S. R. (2013). Diagnosing Autism Spectrum Disorder: who will get a DSM-5 diagnosis? Journal of Child Psychology and Psychiatry, 54(11), 1242-1250. doi: 10.1111/jcpp.12085
Kimura, R., Yoshizaki, K., & Osumi, N. (2018). Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm. In: Kubota, T., Fukuoka, H. (eds) Developmental Origins of Health and Disease (DOHaD). Advances in Experimental Medicine and Biology, vol 1012 (pp. 75-81). Springer, Singapore. doi: 10.1007/978-981-10-5526-3_8
Kong, A., Frigge, M. L., Masson, G., Besenbacher, S., Sulem, P., Magnusson, G., … Stefansson, K. (2012). Rate of de novo mutations and the importance of father’s age to disease risk. Nature, 488(7412), 471-475. doi: 10.1038/nature11396
Lampi, K. M., Hinkka-Yli-Salomäki, S., Lehti, V., Helenius, H., Gissler, M., Brown, A. S., & Sourander, A. (2013). Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort. Journal of Autism and Developmental Disorders, 43(11), 2526-2535. doi: 10.1007/s10803-013-1801-3
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., … Mortensen, P. B. (2005). Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status. American Journal of Epidemiology, 161(10), 916-925. doi: 10.1093/aje/kwi123
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005). Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. Journal of Child Psychology and Psychiatry, 46(9), 963-971. doi: 10.1111/j.1469-7610.2004.00391.x
Lee, P. F., Thomas, R. E., & Lee, P. A. (2015). Approach to autism spectrum disorder: Using the new DSM-V diagnostic criteria and the CanMEDS-FM framework. Canadian Family Physician, 61(5), 421-424.
Liptak, G. S., Benzoni, L. B., Mruzek, D. W., Nolan, K. W., Thingvoll, M. A., Wade, C. M., & Fryer, G. E. (2008). Disparities in Diagnosis and Access to Health Services for Children with Autism: Data from the National Survey of Children’s Health. Journal of Developmental & Behavioral Pediatrics, 29(3), 152-160. doi: 10.1097/dbp.0b013e318165c7a0
Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659-685. doi: 10.1007/bf02172145
Lundstrom, S., Haworth, C. M. A., Carlstrom, E., Gillberg, C., Mill, J., Rastam, M., … Reichenberg, A. (2010). Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies. Journal of Child Psychology and Psychiatry, 51(7), 850-856. doi: 10.1111/j.1469-7610.2010.02223.x
Maimburg, R. D., & Vaeth, M. (2006). Perinatal risk factors and infantile autism. Acta Psychiatrica Scandinavica, 114(4), 257-264. doi: 10.1111/j.1600-0447.2006.00805.x
Mamidala, M. P., Polinedi, A., P T V, P. K., Rajesh, N., Vallamkonda, O. R., Udani, V., … Rajesh, V. (2013). Prenatal, perinatal and neonatal risk factors of Autism Spectrum Disorder: A comprehensive epidemiological assessment from India. Research in Developmental Disabilities, 34(9), 3004-3013. doi: 10.1016/j.ridd.2013.06.019
Muhle, R. A., Reed, H. E., Stratigos, K. A., & Veenstra-VanderWeele, J. (2018). The Emerging Clinical Neuroscience of Autism Spectrum Disorder. A review. JAMA Psychiatry, 75(5), 514-523. doi: 10.1001/jamapsychiatry.2017.4685
Parner, E. T., Baron-Cohen, S., Lauritsen, M. B., Jørgensen, M., Schieve, L. A., Yeargin-Allsopp, M., & Obel, C. (2012). Parental Age and Autism Spectrum Disorders. Annals of Epidemiology, 22(3), 143-150. doi: 10.1016/j.annepidem.2011.12.006
Pedersen, A., Pettygrove, S., Meaney, F. J., Mancilla, K., Gotschall, K., Kessler, D. B., … Cunniff, C. (2012). Prevalence of autism spectrum disorders in Hispanic and non-Hispanic white children. Pediatrics, 129(3), e629-e635. doi: 10.1542/peds.2011-1145
Pinborough-Zimmerman, J., Bilder, D., Bakian, A., Satterfield, R., Carbone, P. S., Nangle, B. E., … McMahon, W. M. (2011). Sociodemographic risk factors associated with autism spectrum disorders and intellectual disability. Autism Research, 4(6), 438-448. doi: 10.1002/aur.224
Reichenberg, A., Gross, R., Sandin, S., & Susser, E. S. (2010). Advancing paternal and maternal age are both important for autism risk. American Journal of Public Health, 100(5), 772-773. doi: 10.2105/ajph.2009.187708
Sanders, S., Ercan-Sencicek, A., Hus, V., Luo, R., Murtha, M., Moreno-De-Luca, D., ... State, M. (2011). Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism. Neuron, 70(5), 863-885. doi: 10.1016/j.neuron.2011.05.002
Sandin, S., Schendel, D., Magnusson, P., Hultman, C., Surén, P., Susser, E., ... Reichenberg, A. (2016). Autism risk associated with parental age and with increasing difference in age between the parents. Molecular Psychiatry, 21(5), 693-700. doi: 10.1038/mp.2015.70
Sasanfar, R., Haddad, S. A., Tolouei, A., Ghadami, M., Yu, D., & Santangelo, S. L. (2010). Paternal age increases the risk for autism in an Iranian population sample. Molecular Autism, 1(1), 2. doi: 10.1186/2040-2392-1-2
Schieve, L. A., Boulet, S. L., Blumberg, S. J., Kogan, M. D., Yeargin-Allsopp, M., Boyle, C. A., … Rice, C (2012). Association between parental nativity and autism spectrum disorder among US-born non-Hispanic white and Hispanic children, 2007 National Survey of Children’s Health. Disability and Health Journal, 5(1), 18-25. doi: 10.1016/j.dhjo.2011.09.001
Shelton, J. F., Tancredi, D. J., & Hertz-Picciotto, I. (2010). Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Research, 3(1), 30-39. doi: 10.1002/aur.116
Siu, A. L., Bibbins-Domingo, K., Grossman, D. C., Baumann, L. C., Davidson, K. W., Ebell, M., ... Pignone, M. P. (2016). Screening for Autism Spectrum Disorder in Young Children. US Preventive Services Task Force Recommendation Statement. JAMA, 315(7), 691-696. doi: 10.1001/jama.2016.0018
Sun, X., Allison, C., Auyeung, B., Baron-Cohen, S., & Brayne, C. (2014). Parental concerns, socioeconomic status, and the risk of autism spectrum conditions in a population-based study. Research in Developmental Disabilities, 35(12), 3678-3688. doi: 10.1016/j.ridd.2014.07.037
Szatmari, P., Paterson, A. D., Zwaigenbaum, L., Roberts, W., Brian, J., Liu, X., … Shih, A. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics, 39(3), 319-328. doi: 10.1038/ng1985
The R Development Core Team. (2008). R: A language and environment for statistical computing. R Development Core Team. Version 2.6.2 (2008-02-08). R Foundation for Statistical Computing.
van Balkom, I. D. C., Bresnahan, M., Vuijk, P. J., Hubert, J., Susser, E., & Hoek, H. W. (2012). Paternal Age and Risk of Autism in an Ethnically Diverse, Non-Industrialized Setting: Aruba. PLoS ONE, 7(9), e45090. doi: 10.1371/journal.pone.0045090
Williams, K., Helmer, M., Duncan, G. W., Peat, J. K., & Mellis, C. M. (2008). Perinatal and maternal risk factors for autism spectrum disorders in New South Wales, Australia. Child: Care, Health and Development, 34(2), 249-256. doi: 10.1111/j.1365-2214.2007.00796.x
Wu, S., Wu, F., Ding, Y., Hou, J., Bi, J., & Zhang, Z. (2017). Advanced parental age and autism risk in children: a systematic review and meta-analysis. Acta Psychiatrica Scandinavica, 135(1), 29-41. doi: 10.1111/acps.12666
Zhang, X., Lv, C., Tian, J., Miao, R., Xi, W., Hertz-Picciotto, I., & Qi, L. (2010). Prenatal and Perinatal Risk Factors for Autism in China. Journal of Autism and Developmental Disorders, 40(11), 1311-1321. doi: 10.1007/s10803-010-0992-0
